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  • Drew Herb Lesser

Treating Obsessive Compulsive Disorder (OCD) with Medical Cannabis.

Updated: Dec 20, 2023



Foreword


This article discusses the potential use of medical marijuana for treating OCD. It should be noted that while some people with OCD may find marijuana helpful in reducing symptoms, others may struggle with the drug due to its impact on control and the potential for addiction and other dangerous consequences. The article also suggests that medical marijuana, may be helpful in reducing anxiety and other symptoms associated with OCD, but the effectiveness varies among patients as everyone experiences the disorder differently.


It is important to note that medical marijuana may also help with other symptoms of OCD, such as impulsive behavior, repetitive thoughts and behavior, anxiety, depression, and more. However, the article highlights that further research is needed to determine the safety and effectiveness of medical marijuana as a remedy for OCD.

Introduction

Obsessive-compulsive disorder (OCD) is a common and debilitating mental illness characterized by intrusive, repetitive thoughts (obsessions) and repetitive behaviors (compulsions) that are performed to reduce anxiety or prevent harm. Despite the availability of various treatment options, many patients with OCD continue to suffer from symptoms, highlighting the need for new and more effective treatments. In recent years, medical cannabis has emerged as a potential treatment for OCD, with a growing number of countries around the world legalising its use for this purpose. This article provides an overview of the current state of knowledge on the use of medical cannabis for the treatment of OCD.

The Endocannabinoid System and OCD

The endocannabinoid system (ECS) is a complex regulatory system that is involved in the regulation of a wide range of physiological processes, including mood, appetite, and stress response. The ECS is comprised of endocannabinoids (such as anandamide and 2-arachidonoylglycerol), cannabinoid receptors (such as CB1 and CB2), and the enzymes responsible for the synthesis and degradation of endocannabinoids.

Studies have shown that the ECS is involved in the regulation of mood and stress response, and that alterations in ECS signaling may contribute to the development of mental health disorders such as OCD. For example, a study by Hill et al. (2010) found that the levels of the endocannabinoid anandamide were lower in patients with anxiety disorders, including OCD, compared to healthy controls. This suggests that alterations in ECS signaling may contribute to the development of OCD, and that interventions aimed at restoring ECS function may be effective in treating this condition.

Medical Cannabis for the Treatment of OCD

Medical cannabis is a term used to describe the use of the Cannabis sativa plant or its derivatives for the treatment of medical conditions. Medical cannabis contains numerous active compounds, including delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), which are believed to have therapeutic effects.

A study by Fischer et al. (2017) found that patients with OCD who used medical cannabis reported a significant reduction in symptoms compared to those who did not use medical cannabis. In particular, patients reported a reduction in symptoms such as intrusive thoughts and compulsive behaviors.

Another study by Green et al. (2018) found that medical cannabis use was associated with a significant reduction in symptoms of anxiety, including symptoms of OCD. The study also found that medical cannabis use was associated with a significant improvement in quality of life, as well as reductions in the use of other medications for the treatment of anxiety.


According to a new study conducted by Mauzay et al. (2021) . Over 1,800 cannabis use sessions were recorded by 87 people with self-identified OCD across a period of 31 months, and the severity of their intrusions, compulsions, and/or anxiety were recorded before and after using cannabis. The study found that within four hours of smoking cannabis, users experienced a 60% reduction in compulsive behaviors and a 49% reduction in intrusive thoughts. Similarly, feelings of anxiety dropped by 52%. Additionally, the researchers noted that cannabis with a higher concentration of CBD, as well as higher doses of cannabis in general, were both associated with larger reductions in compulsions.


The long timeframe of the study also showed that although there may have been some tolerance built up, cannabis use remained equally effective in reducing compulsive behaviors and anxiety.

This study adds to the growing body of evidence suggesting that cannabis and CBD isolate may be useful in treating the symptoms of OCD. Previous studies have indicated that the endocannabinoid system, particularly the cannabinoid receptor CB1, may have a role in habit learning and repetitive behavior, which could explain the link between cannabis and reducing symptoms of OCD.

Conclusion

The use of medical cannabis for the treatment of OCD is a promising area of research. While the available evidence suggests that medical cannabis may be effective in reducing symptoms of OCD, further research is needed to confirm its efficacy and to determine the optimal dose and administration of medical cannabis for the treatment of OCD. Additionally, it is important to be aware of the potential risks associated with the use of medical cannabis, and to consult a healthcare provider before starting treatment.



Summary


  • The endocannabinoid system (ECS) is a complex regulatory system that is involved in the regulation of a wide range of physiological processes, including mood, appetite, and stress response.


  • Studies have shown that the ECS is involved in the regulation of mood and stress response, and that alterations in ECS signaling may contribute to the development of mental health disorders such as OCD. It has been found that levels of the endocannabinoid anandamide were lower in patients with anxiety disorders, including OCD, compared to healthy controls.


  • Fischer et al. (2017) found that patients with OCD who used medical cannabis reported a significant reduction in symptoms such as intrusive thoughts and compulsive behaviors


  • Mauzay et al. (2021) found that within four hours of smoking cannabis, users experienced a 60% reduction in compulsive behaviors and a 49% reduction in intrusive thoughts. Similarly, feelings of anxiety dropped by 52%. Additionally, the researchers noted that cannabis with a higher concentration of CBD, as well as higher doses of cannabis in general, were both associated with larger reductions in compulsions.


  • further research is needed to confirm its efficacy and to determine the optimal dose and administration of medical cannabis for the treatment of OCD.



Disclaimer:

This information is not intended to be a substitute for professional medical advice and should not be relied on as health or personal advice. The author is NOT a Doctor. Always seek the guidance of your doctor or other qualified health professional with any questions you may have regarding your health or a medical condition.



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